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2025 Mercedes-Benz E450 4matic — 3.0L 6-cyl, Automatic 9-spd, AWD
This 2025 Mercedes-Benz E450 4matic (3.0L 6-cyl, Automatic 9-spd, AWD) takes premium gasoline. PREMIUM
25
MPG combined (22 city / 31 hwy)
$3,100
est. fuel cost / year (EPA, 15k mi)
355 g/mi
tailpipe CO₂
The EPA lists this trim as premium because that's the fuel the manufacturer specified for its mileage test. Many such engines will run on regular with slightly lower power and MPG — but check your owner's manual to see whether premium is required or just recommended.
EPA fuel type: Premium · class: Midsize Cars · retrieved 2026-06-14.