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2022 Lexus RX 450h AWD — 3.5L 6-cyl, AV-S6 automatic, AWD
This 2022 Lexus RX 450h AWD (3.5L 6-cyl, AV-S6 automatic, AWD) takes premium gasoline. PREMIUM
30
MPG combined (31 city / 28 hwy)
$2,550
est. fuel cost / year (EPA, 15k mi)
297 g/mi
tailpipe CO₂
The EPA lists this trim as premium because that's the fuel the manufacturer specified for its mileage test. Many such engines will run on regular with slightly lower power and MPG — but check your owner's manual to see whether premium is required or just recommended.
EPA fuel type: Premium · class: Standard Sport Utility Vehicle 4WD · retrieved 2026-06-14.