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2021 Mercedes-Benz E450 4matic All-Terrain (wagon) — 3.0L 6-cyl, Automatic 9-spd, 4WD
This 2021 Mercedes-Benz E450 4matic All-Terrain (wagon) (3.0L 6-cyl, Automatic 9-spd, 4WD) takes premium gasoline. PREMIUM
24
MPG combined (22 city / 28 hwy)
$2,925
est. fuel cost / year (today’s prices, 15k mi)
364 g/mi
tailpipe CO₂
At today's AAA national average price ($4.68/gal, 2026-07-05) — the EPA's own price/date assumption isn't exposed in the public dataset, so we recompute this from the EPA's MPG figure and a sourced current price.
The EPA lists this trim as premium because that's the fuel the manufacturer specified for its mileage test. Many such engines will run on regular with slightly lower power and MPG — but check your owner's manual to see whether premium is required or just recommended.
EPA fuel type: Premium · class: Midsize Station Wagons · engine: 3.0L 6-cyl turbo · transmission: Automatic 9-spd · drive: 4WD · MPG retrieved 2026-07-24.