Does the 2016 Mercedes-Benz E350 4matic (wagon) take premium or regular gas?

The EPA lists the 2016 Mercedes-Benz E350 4matic (wagon) 3.5L 6-cyl, Automatic 7-spd, 4WD as taking premium. Combined MPG is 22, and at today's gas prices that's about $3,191 a year in fuel.

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2016 Mercedes-Benz E350 4matic (wagon) — 3.5L 6-cyl, Automatic 7-spd, 4WD

This 2016 Mercedes-Benz E350 4matic (wagon) (3.5L 6-cyl, Automatic 7-spd, 4WD) takes premium gasoline. PREMIUM

MPG combined (20 city / 26 hwy)

$3,191

est. fuel cost / year (today’s prices, 15k mi)

396 g/mi

tailpipe CO₂

At today's AAA national average price ($4.68/gal, 2026-07-05) — the EPA's own price/date assumption isn't exposed in the public dataset, so we recompute this from the EPA's MPG figure and a sourced current price.

EPA updated its fuel-economy equations again for model year 2017 — mostly affecting hybrids and turbocharged engines — and recalculated 2011-2016 ratings to match, in some cases 1-2 MPG lower. The number above already reflects that update.

The EPA lists this trim as premium because that's the fuel the manufacturer specified for its mileage test. Many such engines will run on regular with slightly lower power and MPG — but check your owner's manual to see whether premium is required or just recommended.

EPA fuel type: Premium · class: Midsize Station Wagons · engine: 3.5L 6-cyl · transmission: Automatic 7-spd · drive: 4WD · MPG retrieved 2026-07-24.