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2012 Lexus RX 450h — 3.5L 6-cyl, AV-S6 automatic, FWD
This 2012 Lexus RX 450h (3.5L 6-cyl, AV-S6 automatic, FWD) takes premium gasoline. PREMIUM
29
MPG combined (31 city / 28 hwy)
$2,650
est. fuel cost / year (EPA, 15k mi)
—
tailpipe CO₂
The EPA lists this trim as premium because that's the fuel the manufacturer specified for its mileage test. Many such engines will run on regular with slightly lower power and MPG — but check your owner's manual to see whether premium is required or just recommended.
EPA fuel type: Premium · class: Sport Utility Vehicle - 2WD · retrieved 2026-06-14.