2021 Nissan Titan 4WD PRO-4X MPG & Specs — Real-World vs EPA, All Trims
Every gas trim of this model takes premium.
Is the 2021 Nissan Titan 4WD PRO-4X good on gas?
At up to 17 MPG combined, the 2021 Nissan Titan 4WD PRO-4X is about average for a Standard Pickup Trucks 4WD — that class averages about 16.5 MPG across 1,581 EPA-tested versions, so it's middle-of-the-road for its size.
Real-world MPG vs the EPA number
The EPA figures above come from a standardized dynamometer test, not the open road — real-world MPG typically runs a bit lower depending on your driving, climate and terrain. That's true of every car on this site, old or new.
At today's AAA national average price — $4.68/gal for premium gas as of 2026-07-05 — the most efficient trim runs about $4,129/year (roughly $344/month, about $27.53 per 100 miles) at the EPA's assumed 15,000 miles/year, using an estimated 882 gallons a year. We don't estimate a cost-per-fill since exact tank size isn't in the public EPA dataset, but the per-100-mile figure scales to any tank. Current national average gas prices →
2021 Nissan Titan 4WD PRO-4X trims & fuel economy
| Trim (engine / transmission) | Fuel | MPG | Fuel/yr (today's price) |
|---|---|---|---|
| 5.6L 8-cyl, S9 automatic, 4WD | PREMIUM | 17 | $4,129 |
2021 Nissan Titan 4WD PRO-4X specs
What the EPA test-car listings record for this model year — every combination sold is a row in the trims table above.
| Engine options | 5.6L 8-cyl |
| Transmission | S9 automatic |
| Drive type | 4WD |
| EPA body class | Standard Pickup Trucks 4WD |
| Fuel | Premium |
| Tailpipe CO₂ | 518 g/mi |
Similar cars (Standard Pickup Trucks 4WD)
Cars that take premium · Cheapest cars to fuel · Where fuel grade depends on the trim · Fuel guides
1 trim(s) · EPA FuelEconomy.gov data retrieved 2026-07-24 · fuel prices AAA national average as of 2026-07-05.