2016 Lexus GS 450h MPG & Specs — Real-World vs EPA, All Trims

Is the 2016 Lexus GS 450h good on gas?

Real-world MPG vs the EPA number

The EPA figures above come from a standardized dynamometer test, not the open road — real-world MPG typically runs a bit lower depending on your driving, climate and terrain. That's true of every car on this site, old or new.

EPA updated its fuel-economy equations again for model year 2017 — mostly affecting hybrids and turbocharged engines — and recalculated 2011-2016 ratings to match, in some cases 1-2 MPG lower. The number above already reflects that update.

At today's AAA national average price — $4.68/gal for premium gas as of 2026-07-05 — the most efficient trim runs about $2,265/year (roughly $189/month, about $15.10 per 100 miles) at the EPA's assumed 15,000 miles/year, using an estimated 484 gallons a year. We don't estimate a cost-per-fill since exact tank size isn't in the public EPA dataset, but the per-100-mile figure scales to any tank. Current national average gas prices →

2016 Lexus GS 450h trims & fuel economy

2016 Lexus GS 450h specs

What the EPA test-car listings record for this model year — every combination sold is a row in the trims table above.

Other years of the Lexus GS 450h

Similar cars (Midsize Cars)

Cars that take premium · Cheapest cars to fuel · Where fuel grade depends on the trim · Fuel guides

1 trim(s) · EPA FuelEconomy.gov data retrieved 2026-07-24 · fuel prices AAA national average as of 2026-07-05.