2010 Mercedes-Benz E350 4matic MPG & Specs — Real-World vs EPA, All Trims
Every gas trim of this model takes premium.
Is the 2010 Mercedes-Benz E350 4matic good on gas?
At up to 19 MPG combined, the 2010 Mercedes-Benz E350 4matic is worse than average for a Midsize Cars — that class averages about 23.0 MPG across 5,710 EPA-tested versions, so it's on the thirsty side for its size.
Real-world MPG vs the EPA number
The EPA figures above come from a standardized dynamometer test, not the open road — real-world MPG typically runs a bit lower depending on your driving, climate and terrain. That's true of every car on this site, old or new.
At today's AAA national average price — $4.68/gal for premium gas as of 2026-07-05 — the most efficient trim runs about $3,695/year (roughly $308/month, about $24.63 per 100 miles) at the EPA's assumed 15,000 miles/year, using an estimated 789 gallons a year. We don't estimate a cost-per-fill since exact tank size isn't in the public EPA dataset, but the per-100-mile figure scales to any tank. Current national average gas prices →
2010 Mercedes-Benz E350 4matic trims & fuel economy
| Trim (engine / transmission) | Fuel | MPG | Fuel/yr (today's price) |
|---|---|---|---|
| 3.5L 6-cyl, Automatic 7-spd, 4WD | PREMIUM | 19 | $3,695 |
2010 Mercedes-Benz E350 4matic specs
What the EPA test-car listings record for this model year — every combination sold is a row in the trims table above.
| Engine options | 3.5L 6-cyl |
| Transmission | Automatic 7-spd |
| Drive type | 4WD |
| EPA body class | Midsize Cars |
| Fuel | Premium |
Other years of the Mercedes-Benz E350 4matic
Similar cars (Midsize Cars)
Cars that take premium · Cheapest cars to fuel · Where fuel grade depends on the trim · Fuel guides
1 trim(s) · EPA FuelEconomy.gov data retrieved 2026-07-24 · fuel prices AAA national average as of 2026-07-05.