2006 GMC Sierra 1500 4WD MPG & Specs — Real-World vs EPA, All Trims
It depends on the trim. Some versions take premium and some take regular — check your exact engine/transmission below.
Is the 2006 GMC Sierra 1500 4WD good on gas?
At up to 15 MPG combined, the 2006 GMC Sierra 1500 4WD is worse than average for a Standard Pickup Trucks 4WD — that class averages about 16.5 MPG across 1,581 EPA-tested versions, so it's on the thirsty side for its size.
Real-world MPG vs the EPA number
The EPA figures above come from a standardized dynamometer test, not the open road — real-world MPG typically runs a bit lower depending on your driving, climate and terrain. That's true of every car on this site, old or new.
This 2006 model was originally EPA-tested under the pre-2008 2-cycle method, which didn't account for highway speeds over 60 mph, air-conditioner use, or cold starts. When EPA overhauled the test for model year 2008, city ratings fell by about 12% and highway by about 8% on average industry-wide — and EPA retroactively adjusted every 1984-2007 rating to the stricter standard so old and new cars could be compared fairly. The MPG above is already on that modern scale — the window sticker on this car when it was new likely showed a higher, pre-2008-method number.
At today's AAA national average price — $3.80/gal for regular gas as of 2026-07-05 — the most efficient trim runs about $3,800/year (roughly $317/month, about $25.33 per 100 miles) at the EPA's assumed 15,000 miles/year, using an estimated 1,000 gallons a year. We don't estimate a cost-per-fill since exact tank size isn't in the public EPA dataset, but the per-100-mile figure scales to any tank. Current national average gas prices →
2006 GMC Sierra 1500 4WD trims & fuel economy
| Trim (engine / transmission) | Fuel | MPG | Fuel/yr (today's price) |
|---|---|---|---|
| 4.3L 6-cyl, Automatic 4-spd, AWD | REGULAR | 15 | $3,800 |
| 4.3L 6-cyl, 5-spd manual, AWD | REGULAR | 15 | $3,800 |
| 4.8L 8-cyl, Automatic 4-spd, AWD | REGULAR | 15 | $3,800 |
| 4.8L 8-cyl, 5-spd manual, AWD | REGULAR | 15 | $3,800 |
| 5.3L 8-cyl, Automatic 4-spd, AWD | REGULAR | 15 | $3,800 |
| 5.3L 8-cyl, Automatic 4-spd, AWD | FLEX-FUEL | 15 | $4,150 |
| 6.0L 8-cyl, Automatic 4-spd, AWD | PREMIUM | 14 | $5,014 |
2006 GMC Sierra 1500 4WD specs
What the EPA test-car listings record for this model year — every combination sold is a row in the trims table above.
| Engine options | 4.3L 6-cyl · 4.8L 8-cyl · 5.3L 8-cyl · 6.0L 8-cyl |
| Transmission | Automatic 4-spd · 5-spd manual |
| Drive type | AWD |
| EPA body class | Standard Pickup Trucks 4WD |
| Fuel | Varies by trim |
Other years of the GMC Sierra 1500 4WD
Similar cars (Standard Pickup Trucks 4WD)
Cars that take premium · Cheapest cars to fuel · Where fuel grade depends on the trim · Fuel guides
7 trim(s) · EPA FuelEconomy.gov data retrieved 2026-07-24 · fuel prices AAA national average as of 2026-07-05.